The Hip

Level III involves the creation of biokompozitsionnyh containing materials as the main components of bone and bioactive substances. In a question-answer forum Unum was the first to reply. The latter include growth factors, morphogenetic proteins and other components of the bone matrix. Bioactive substances assigned the role of activators and regulators physiological tissue regeneration. In addition, at the stage of implantation in the composition of such materials can be included, and a variety of transplanted progenitor cells. (Not to be confused with Principles for Responsible Investment (PRI)!). Currently, the creation of biokompozitsionnyh materials in Russia has become a priority 3. Recently active development and technological level IV, characterized by the creation of synthetic materials biokompozitsionnyh based on modern technology.

The latter include steriolitograficheskoe up tissues 4, the technology of 3-D implants 5,6, liquid-distributing simulation 7 and the creation fazovoizmenyayuschee implants 8. Connection these methods with high accuracy to copy objects and fabric to create materials with well-defined size, geometry and distribution of pores, as well as fully play architecture of the organ site and its internal channels in the created implant. Unfortunately, soon put into practice a Russian textile banks such technologies is not possible for many reasons. In the presence of specific technical capabilities and their own experience, in a tissue bank CITO over the last ten years have been developed and introduced into medical practice in a number of new bioplastic materials second and third technological levels. First of all, it's – 'Perfoost', which is a freeze-dried demineralized bone alloimplantaty (DKI), made in the form of sheets, shavings, chips, etc.

Different degrees of demineralization and geometry data have allowed bioplastic materials to use it in many areas of reconstructive surgery is to fill in any bone defects and to accelerate the process of bone formation 9,10. For practical Medicine CITO Bank DKI have also been proposed, made from the bones of the cranial vault. Due to their large size and high degree of demineralization of this material is now widely used in orthopedics at conduct an audit replacement for the replacement of major defects of the bottom wall of the acetabulum and the hip.

The Effects

In the literature there are sporadic reports on the impact of sGAG on repair of bone tissue 15 however, their role in her recovery so far been studied extremely inadequately. It is also known that bone strength due to the presence in it of hydroxyapatite (HA). However, in the manufacture of many plastic materials HA bone is usually removed. This is to ensure that, after implantation of the organic matrix of bone was the most accessible to the processes of remodeling and bone formation of the recipient. On the other hand, if prepare materials of natural HA, they are usually quite brittle and their strength properties significantly lower than the native bone. Consequently, the strength of bone depends primarily on the structural interaction between collagen and HA 16. The article 'Osteomatriks' almost completely preserved collagen and hydroxyapatite structure of the native bone, but the materials are completely devoid of antigenicity. Great advantage of the materials 'Allomatriks-implant' and 'Osteomatriks' is the fact that they contain bone sGAG, affine-connected and with collagen and HA, which distinguishes them from those in the world of unique and greatly enhances their osteogenic potential.

It is these properties of these materials can effectively use them in cases of osteogenesis imperfecta (false joints of different etiologies, congenital bone, etc.) and other bone pathologies (dental, hand surgery, etc.) 17-20. Thus, summing up the above, we can say with confidence that the tissue bank issued CITO bioplastic materials second and third technological level, have a marked effect on the regeneration of bone tissue, have no side effects and have osteoconductive and osteoinductive properties. That is why when their clinical application received more than 93% of the positive results of treatment in patients with various pathologies of the locomotor apparatus. References: 1. Salai M., Brosh T., Keller N. et al. The effects of prolonged cryopreservation on the biomechanical properties of bone allografts: A microbiological, histological and mechanical study.